Sophoraflavanone G

Name	Sophoraflavanone G
Synonyms	vexibinol Sophoraavanone G Sophoraflavanone G (2S)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-[(2S)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one (S)-2,3-Dihydro-5,7-dihydroxy-2-(2,4-dihydroxyphenyl)-6-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one (2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2,4-dihydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one,2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-,(2S)-
CAS	97938-30-2

Molecular Formula	C25H28O6
Molar Mass	424.49
Density	1.266±0.06 g/cm
Melting Point	173-175℃
Boling Point	659.3±55.0 °C(Predicted)
Specific Rotation(α)	36.5 (c, 1.1 in MeOH)
pKa	7.66±0.40(Predicted)
Storage Condition	2-8℃
Physical and Chemical Properties	Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.
Use	phytoalexin
In vitro study	Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cellsin a dose-dependent manner. Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochromec from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathway Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC 50 value of 29.7 ± 5.2 μM<.br>

biological activity	Sophoraflavanone G (Kushenol F) is extracted from Sophora flavescens and has anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cell apoptosis (apoptosis) by inhibiting MAPK-related pathways.
target	IC50: 29.7 μM (MDA-MB-231 cell)
in vitro study	Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cellsin a pose-dependent manner. Sophoraflavanone G (0 -100 μ M; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochromec from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathway Sophoraflavanone G (0 -40 μ m; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC 50 value of 29.7±5.2 μ m <.br>
chemical properties	yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.
use	anti-tumor, hypoglycemic, antibacterial and insecticidal, anti-arrhythmia. used for content determination/identification/pharmacological experiment, etc.

Last Update：2024-04-09 21:01:54

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